Meaning : An emotion of great sadness associated with loss or bereavement.
Example :
He tried to express his sorrow at her loss.
Meaning : Sadness associated with some wrong done or some disappointment.
Example :
He drank to drown his sorrows.
He wrote a note expressing his regret.
To his rue, the error cost him the game.
Synonyms : regret, rue, ruefulness
Meaning : Something that causes great unhappiness.
Example :
Her death was a great grief to John.
Synonyms : grief
Meaning : The state of being sad.
Example :
She tired of his perpetual sadness.
Synonyms : sadness, sorrowfulness