Meaning : A state in which all hope is lost or absent.
Example :
In the depths of despair.
They were rescued from despair at the last minute.
Courage born of desperation.
Synonyms : desperation
Meaning : The feeling that everything is wrong and nothing will turn out well.
Example :
They moaned in despair and dismay.
One harsh word would send her into the depths of despair.
The general feeling that some desire will be fulfilled.
In spite of his troubles he never gave up hope.